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Recruiting

A Study of Cabiralizumab Given With Nivolumab With and Without Chemotherapy in Patients With Advanced Pancreatic Cancer - CA025-006

Updated: 03 July, 2018   |   ClinicalTrials.gov

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the trial guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 14

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Active Comparator: Arm A
Drug: Irinotecan Hydrochloride Drug: Leucovorin Drug: Gemcitabine Drug: Fluorouracil Drug: Onivyde Drug: Nab-paclitaxel
Experimental: Arm B
Biological: Cabiralizumab Biological: Nivolumab
Experimental: Arm C
Drug: Gemcitabine Biological: Nivolumab Drug: Nab-paclitaxel Biological: Cabiralizumab
Experimental: Arm D
Drug: Leucovorin Drug: Oxaliplatin Drug: Fluorouracil Biological: Nivolumab Biological: Cabiralizumab

Key Eligibility Criteria

Inclusion Criteria: - Must have histological or cytological confirmed diagnosis of locally advanced or metastatic adenocarcinoma of the pancreas, which has progressed on or after one line of chemotherapy - ECOG Performance status 0-1 - Adequate organ functions - Measurable disease Exclusion Criteria: - Suspected or known CNS metastasis - Participants with active, known, or suspected autoimmune disease - Uncontrolled or significant cardiovascular disease - Prior exposure to selected immune cell-modulating antibody regimens

Have questions? Call 855-907-3286 or Email Us

Have questions?
Call 855-907-3286 or Email Us