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BMS Active Not Yet Recruiting Study icon

Active, Not Recruiting

Trial ID CA021-002  |   NCT03251924

A Dose Escalation and Combination Immunotherapy Study to Evaluate BMS-986226 Alone or in Combination With Nivolumab or Ipilimumab in Patients With Advanced Solid Tumors

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Sorry, this study is no longer accepting new participants, but is still ongoing.
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Summary

  • Phase 1/Phase 2
  • Male and Female Gender icon
  • 18+
    Age Range
  • BMS Active Not Yet Recruiting Study icon
    Active, Not Recruiting

Overview

The purpose of this study is to investigate BMS-986226 administered alone or in combination with nivolumab or ipilimumab.

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Advanced solid tumors - Histological or cytological confirmation of a malignancy that is advanced (metastatic and/or unresectable) with measureable disease as defined by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 or PCWG3 (prostate only). - At least 1 lesion accessible for biopsy in addition to the target lesion - Participants must have received, and then progressed or been intolerant to, at least 1 standard treatment regimen - Eastern Cooperative Oncology Group (ECOG) performance status ≤2 Exclusion Criteria: - Participants with active central nervous system (CNS) metastases, untreated CNS metastases, or with the CNS as the only site of disease are excluded (controlled brain metastases will be allowed to enroll) - Participants with carcinomatous meningitis - Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the prostate, cervix, or breast - Active, known, or suspected autoimmune disease - Uncontrolled or significant cardiovascular disease - Participants with known allergies to egg products, neomycin and tetanus toxoid. - Prior adverse reaction to tetanus toxoid- containing vaccines. Other protocol defined inclusion/exclusion criteria could apply

Treatment Options

Study Arms

ASSIGNED INTERVENTION

Study Arms

Experimental: BMS-986226

ASSIGNED INTERVENTION
  • Drug: BMS-986226 Biological: Tetanus Vaccine

Study Arms

Experimental: BMS-986226 and Ipilimumab

ASSIGNED INTERVENTION
  • Biological: Tetanus Vaccine Biological: Ipilimumab Drug: BMS-986226

Study Arms

Experimental: BMS-986226 and Nivolumab

ASSIGNED INTERVENTION
  • Biological: Tetanus Vaccine Biological: Nivolumab Drug: BMS-986226