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This clinical trial is no longer recruiting patients.

Recruiting

A Study to Test Combination Treatments in Patients With Advanced Gastric Cancer - CA018-003

Updated: 19 September, 2019   |   ClinicalTrials.gov

Print Friendly Summary

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Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 2

    Phase

  • Gender(s)

  • 18-110

    Age Range

  • 31

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Ipi with rucaparib Combination
Drug: Rucaparib
Experimental: nivo and BMS-986205 Combination
Biological: BMS-986205 Biological: Nivolumab
Experimental: nivo and Relatlimab Combination
Biological: Relatlimab Biological: Nivolumab
Experimental: Nivo and rucaparib Combination
Drug: Rucaparib
Experimental: nivo with ipi and rucaparib
Drug: Rucaparib
Active Comparator: Nivolumab (nivo) and Ipilimumab (ipi) Combination
Biological: Ipilimumab Biological: Nivolumab

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Advanced Gastric Cancer - Must have full activity or, if limited, must be able to walk and carry out light activities such as light house work or office work - Must have at least 1 lesion with measurable disease - All participants must have inoperable, advanced, or metastatic EC, GC or GEJ carcinoma and have histologically confirmed predominant adenocarcinoma or squamous cell carcinoma. (sub protocol C) Exclusion Criteria: - Patients/subjects with HER2 positive tumor that have not been treated with trastuzumab prior to enrollment - Must not have suspected or known central nervous system metastases unless adequately treated - Patients/subjects with autoimmune disease - Patients/subjects who need daily oxygen therapy - Participants who are considered to be refractory or resistant to platinum agents (sub protocol c) - Participants who have inability to swallow capsules or pills (sub protocol c) - Current or recent (within 3 months of study treatment administration) gastrointestinal disease that could interfere with absorption of orally administered systemic treatments (sub protocol c) - Participants with diagnosis or history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). (sub protocol C) - Prior treatment with a PARP inhibitor (such as rucaparib, olaparib, niraparib, talozaparib, etc.) or a targeted DNA damage response inhibitor (such as ATM or ataxia telangiectasia and Rad3-related protein [ATR] inhibitor). (sub protocol C) Other protocol defined inclusion/exclusion criteria could apply

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Side Effects (Adverse Events) and other reportable events are defined here
Report Side Effects (Adverse Events) or Product Quality Complaints: Medical Information

Have questions? Live support is available 24/7 - Call 855-907-3286 or email clinical.trials@bms.com

Have questions? Live support is available 24/7 -
Call 855-907-3286 or email clinical.trials@bms.com