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Recruiting

An Investigational Immuno-therapy Study to Evaluate the Safety and Effectiveness of Experimental Medication BMS-986207 by Itself and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread - CA020-002

Updated: 27 August, 2018   |   ClinicalTrials.gov

CONSIDERING THIS TRIAL?
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Use the trial guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
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Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 9

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part 1A- Dose Escalation- Monotherapy
Drug: BMS-986207
Experimental: Part 1B- Dose Escalation- Combination Therapy
Drug: BMS-986207 Biological: Nivolumab
Experimental: Part 2A- Expansion- Monotherapy
Drug: BMS-986207
Experimental: Part 2B- Expansion- Combination Therapy
Drug: BMS-986207 Biological: Nivolumab

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Women and men ≥18 years of age with Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 - Must have received and progressed on or failed one standard/approved treatment for cancer type, if available - At least 4 weeks since any previous treatment for cancer - Subject must consent to pretreatment and on treatment tumor biopsies - At least one lesion with measurable disease at baseline - Adequate organ and marrow function Exclusion Criteria: - Patients with primary brain tumors or primary tumors with central nervous system metastases as only location of disease. Controlled brain metastases are permitted - Prior organ transplant - Participants with second/other active cancers requiring current treatment - Uncontrolled/significant heart disease - History of chronic hepatitis, Positive test for Hepatitis B virus surface antigen or Hepatitis C antibody (except participants with liver cancer) or Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome(HIV/AIDS) - Active/uncontrolled autoimmune disease - Active infection Other protocol defined inclusion/exclusion criteria could apply

Have questions? Call 855-907-3286 or Email Us

Have questions?
Call 855-907-3286 or Email Us