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Active, Not Recruiting

An Investigational Immuno-therapy Study to Determine the Safety of Urelumab Given in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkin's Lymphoma - CA186-107

Updated: 30 January, 2019   |   ClinicalTrials.gov

Print Friendly Summary

Print this page and the trial guide to help you talk with your doctor.
Use the Study Participants Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2


  • Gender(s)

  • 18+

    Age Range

  • Active, Not Recruiting

Treatment Options

Study Arms
Experimental: Dose Escalation and Cohort expansion: Urelumab + Nivolumab
Biological: Urelumab Biological: Nivolumab

Key Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - For Dose Escalation: - Subjects with any previously treated advanced (metastatic or refractory) solid tumor type and B-cell non-Hodgkin lymphoma - For Cohort Expansion: - Subjects must have a previously treated advanced solid tumor or B cell non-Hodgkin's lymphoma to be eligible - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 - For certain subjects, willing and able to provide pre-treatment and on-treatment fresh tumor biopsy - Women of child-bearing potential and men must use an acceptable method of contraception during treatment and for 23 weeks after treatment for women and 31 weeks for men Exclusion Criteria: - Known central nervous system metastases or central nervous system as the only source of disease - Other concomitant malignancies (with some exceptions per protocol) - Active, known or suspected autoimmune disease - Uncontrolled or significant cardiovascular disease - History of hepatitis (B or C) - History of active or latent tuberculosis

Have questions? Call 855-907-3286 or Email Us

Have questions?
Call 855-907-3286 or Email Us