Inclusion Criteria:
- For Dose escalation: subjects with cervical, ovarian, bladder and colorectal cancer
(CRC), head and neck, gastric and hepatocellular cancer naive to immuno-oncology
agents; 1st line melanoma and 1st line/2nd line NSCLC; Renal Cell Carcinoma naive to
IO; NSCLC progressing while on or after therapy with anti-PD1/anti-PDL-1 and melanoma
subjects progressed while-on or after treatment with anti-PD1 or anti-PDL1 with or
without anti-CTLA-4.
- For Dose Expansion: all of the above in escalation except for cervical, ovarian, and
CRC
- Progressed, or been intolerant to, at least one standard treatment regimen, except for
participants in 1st line cohorts.
- ECOG performance status between 0 and 2
- At least 1 lesion with measurable disease at baseline
- Availability of an existing tumor biopsy sample (and consent to allow pre-treatment
tumor biopsy)
Exclusion Criteria:
- Primary central nervous system (CNS) tumors or solid tumors with CNS metastases as the
only site of active disease
- Autoimmune disease
- Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed
consent
- Uncontrolled CNS metastases
Other protocol defined inclusion/exclusion criteria could apply
Active, Not Recruiting
