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Szukaj Study Connect
  • NCT07204418

Recruiting

A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Administration in Healthy Adult Participants - CN012-0012

Zaktualizowano: 12 listopad, 2025   |   ClinicalTrials.gov

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Szczegóły badania

  • Phase 1

    Etap

  • Płeć

  • 18-65

    Zakres wieku

  • 3

    Lokalizacje

  • Recruiting

Opcje leczenia

Grupy badania
PRZYPISANA INTERWENCJA
Experimental: KarXT
Drug: Xanomeline/ Trospium Chloride

Kluczowe kryteria kwalifikacyjne

Inclusion Criteria: - Participant must be healthy male and female (INOCBP) participants as determined by no clinically significant deviation from normal in medical history, physical examination, 12-lead electrocardiogram (ECG), vital signs (VS), and clinical laboratory determinations. - Participant must be a normal/extensive, intermediate, poor, or ultrarapid CYP2D6 metabolizer. - Participant must have body mass index (BMI) of 18.0 to 32.0 kg/m2, inclusive. Exclusion Criteria: - Participants must not have evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, 12-lead ECG, or clinical laboratory determinations beyond what is consistent with the target population reference ranges. - Other protocol-defined Inclusion/Exclusion criteria apply.