Inclusion Criteria: - Aged ≥18 years at index date. - Have a confirmed diagnosis of schizophrenia before index date. - Receipt of an initial prescription order for xanomeline and trospium chloride (XT) and plan to fill and initiate such therapy. - Provide a signed and dated Institutional Review Board (IRB)/Independent Ethics Committee (IEC)-approved written informed consent form (ICF) in accordance with regulatory, local, and institutional guidelines. - Agree to use an electronic device to record, or provide paper entry of, patient-reported outcomes (in English or Spanish). - English or Spanish speaking. Exclusion Criteria: - Participation in an interventional study within the last 30 days or plan to participate in such study at the time of eligibility screening. - Evidence of use of XT prior to time of eligibility screening.