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Recruiting

An Investigational Immunotherapy Study of BMS-986249 Alone and in Combination With Nivolumab in Solid Cancers That Are Advanced or Have Spread - CA030-001

Updated: 25 June, 2019   |   ClinicalTrials.gov

Print Friendly Summary

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 32

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Part 1A
Biological: BMS-986249
Experimental: Part 1B
Biological: Nivolumab Biological: BMS-986249
Experimental: Part 2A Arm A
Biological: Nivolumab Biological: BMS-986249
Experimental: Part 2A Arm B
Biological: Nivolumab Biological: BMS-986249
Experimental: Part 2A Arm C
Biological: Nivolumab Biological: BMS-986249
Experimental: Part 2A Arm D
Biological: Nivolumab Biological: Ipilimumab
Experimental: Part 2A Arm E
Biological: Nivolumab

Key Eligibility Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Histologic or cytologic confirmation of a solid tumor that is advanced (metastatic, recurrent, and/or unresectable) with measurable disease and have at least 1 lesion accessible for biopsy - Eastern Cooperative Oncology Group Performance Status of 0 or 1 - Some participants must have received, and then progressed, relapsed, or been intolerant to, at least 1 standard treatment regimen in the advanced or metastatic setting according to solid tumor histologies - Prior anti-cancer treatments such as chemotherapy, radiotherapy, or hormonal are permitted for some patients - Understand and sign an IRB/IEC-approved ICF prior to any study-specific evaluation - Willing and able to comply with all study procedures Exclusion Criteria: - Participants with primary CNS malignancies, tumors with CNS metastases as the only site of disease, active brain metastases, or leptomeningeal metastasis will be excluded - Active, known, or suspected autoimmune disease - Participants with other active malignancy requiring concurrent intervention Other protocol defined inclusion/exclusion criteria could apply