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Not Yet Recruiting

An Investigational Immuno-therapy Study of Relatlimab Plus Nivolumab Compared to Various Standard-of-Care Therapies in Previously Treated Participants With Recurrent, Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma - CA224-061

Updated:   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
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Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
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Trial Details

  • Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 78

    Location(s)

  • Not Yet Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Cohort A: nivolumab + paclitaxel
Drug: Paclitaxel Biological: Nivolumab
Active Comparator: Cohort A: ramucirumab + paclitaxel
Drug: Ramucirumab Drug: Paclitaxel
Experimental: Cohort A: relatlimab + nivolumab + paclitaxel
Drug: Paclitaxel Biological: Nivolumab Biological: Relatlimab + Nivolumab
Active Comparator: Cohort B: nivolumab
Biological: Nivolumab
Experimental: Cohort B: relatlimab + nivolumab
Biological: Nivolumab Biological: Relatlimab + Nivolumab
Experimental: Cohort C: relatlimab + nivolumab
Biological: Nivolumab Biological: Relatlimab + Nivolumab

Key Eligibility Criteria

For more information regarding Bristol Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Histologically or cytologically confirmed locally advanced or recurrent or metastatic GC or GEJ adenocarcinoma that is considered incurable by local therapies such as radiation or surgery - Evidence of progressive disease (PD) on at least one prior platinum- and fluoropyrimidine-containing chemotherapy regimen - Available tumor tissue for biomarker analysis Exclusion Criteria: - Must not have squamous cell or undifferentiated GC or GEJ - Untreated known central nervous system (CNS) metastases - Uncontrolled or significant cardiovascular disease Other protocol defined inclusion/exclusion criteria could apply

We strongly recommend you contact BMS to report Side Effects (Adverse Events)
Side Effects (Adverse Events) and other reportable events are defined here
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