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Recruiting

An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) - CA209-498

Updated: 14 January, 2019   |   ClinicalTrials.gov

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CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participant's Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.
Print this page CA209-498
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Trial Details

  • Phase 3

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 36

    Location(s)

  • Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Nivolumab + Radiotherapy Arm
Radiation: Radiotherapy Drug: Nivolumab
Active Comparator: Temozolomide + Radiotherapy Arm
Radiation: Radiotherapy Drug: Temozolomide

Key Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - Males and Females, age ≥ 18 years old - Newly-diagnosed brain cancer or tumor called glioblastoma or GBM - Tumor test result shows MGMT unmethylated type - Karnofsky performance status of ≥ 70 (able to care for self) Exclusion Criteria: - Prior treatment for GBM (other than surgical resection) - Any known tumor outside of the brain - Recurrent or secondary GBM - Active known or suspected autoimmune disease - Biopsy with less than 20% of tumor removed

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