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Active, Not Recruiting

An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread. - CA009-002

Updated: 16 April, 2018   |   ClinicalTrials.gov

Print Friendly Summary

CONSIDERING THIS TRIAL?
Print this page and the trial guide to help you talk with your doctor.
Use the Study Participants Guide to navigate the process of participating in a clinical trial. Understand key factors to consider before deciding and get questions to ask your healthcare team.

Trial Details

  • Phase 1/Phase 2

    Phase

  • Gender(s)

  • 18+

    Age Range

  • 18

    Location(s)

  • Active, Not Recruiting

Treatment Options

Study Arms
ASSIGNED INTERVENTION
Experimental: Combination therapy - BMS-986156 + Nivolumab (Dose Escalation)
Drug: Nivolumab Drug: BMS-986156
Experimental: Combination therapy - BMS-986156 + Nivolumab (Dose Expansion)
Drug: Nivolumab Drug: BMS-986156
Experimental: Mono therapy - BMS-986156 (Dose Escalation)
Drug: BMS-986156
Experimental: Mono therapy - BMS-986156 (Dose Expansion)
Drug: BMS-986156

Key Eligibility Criteria

For more information regarding BMS clinical trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: - For Dose Escalation: - Subjects with any previously treated advanced (metastatic or refractory) solid tumor - For Cohort Expansion: - Subjects must have a previously treated advanced solid tumor to be eligible - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 - Willing and able to provide pre-treatment and on-treatment fresh tumor biopsy - Women of child-bearing potential and men must use an acceptable method of contraception during treatment and for 23 weeks after treatment for women and 31 weeks for men Exclusion Criteria: - Known central nervous system metastases or central nervous system as the only source of disease - Other concomitant malignancies (with some exceptions per protocol) - Active, known or suspected autoimmune disease - Uncontrolled or significant cardiovascular disease - History of active or chronic hepatitis (e.g. Hep B or C) - Impaired liver or bone marrow function - Major surgery less than 1 month before start of the study

Have questions? Email Us

Have questions?
Email Us